Digitalization brings pros and cons to labor relations. Since the COVID-19 pandemic, digital well-being has become a topic for human resource departments due to telework risks at the home office. Some employees work for longer hours, face higher demands, and become unable to switch off. So, they get under stress and suffer from musculoskeletal disorders. The paper aims at the impact of the home office on employees' well-being and outlines which practices can be used to maintain work-life balance and digital well-being at the home office. The paper uses a combination of on-the-desk analysis of secondary sources, a questionnaire survey in the Czech Republic in 2022, and one case study based on semi-structured interviews with human resources managers about several aspects of sustainable work at the home office in 2023. Findings show that it is essential for employers and employees to work together to ensure a safe and healthy home office environment. Regular communication, training, and adherence to occupational safety and health guidelines can help mitigate risks and promote well-being for remote workers. As technology becomes more integrated into daily lives, it is crucial to establish healthy boundaries and habits to avoid the harmful effects of excessive screen time and digital overload. Human resource management identifies practices and accents training to promote sustainable work at the home office, like setting boundaries between home and work tasks, time management, and physical and mental health care.