This scholar paper is aimed to publish the explosion parameters of carbon monoxide / methane and air mixtures. This data could be used by various commercial companies to establish explosion safety rules for the use of these mixtures. During this work, we studied the flammable gases separately and then their mixtures. First, the explosion parameters were obtained by numerical simulation. Secondly, explosion tests were carried out in the 20-L explosion vessel for different conditions (variation in initial temperature and concentration ratio of the mixture). Finally, all the results obtained were compared with the numerical predictions in order to obtain a complete information for appropriate safety solutions.